Blar i forfatter "Oksenych, Valentyn"
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DNA Damage Response
Oksenych, Valentyn; Kainov, Denis (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19) -
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)
Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar; Kainov, Denis (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-24)Viruses can cross species barriers and cause unpredictable outbreaks in man with substantial economic and public health burdens. Broad-spectrum antivirals, (BSAs, compounds inhibiting several human viruses), and BSA-containing drug combinations (BCCs) are deemed as immediate therapeutic options that fill the void between virus identification and vaccine development. Here, we present DrugVirus.info ... -
Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models
Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-12)Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing ... -
Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation
Ragunathan, Kalaiyarasi; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-16)Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiotherapy to target tumors. In mammalian cells, ionizing radiation induces various types of DNA damages ... -
Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI
Castaneda Zegarra, Sergio Miguel; Zhang, Qindong; Alirezaylavasani, Amin; Fernandez-Berrocal, Marion Silvana; Yao, Rouan; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-07)Non-homologous end-joining (NHEJ) is a DNA repair pathway required to detect, process, and ligate DNA double-stranded breaks (DSBs) throughout the cell cycle. The NHEJ pathway is necessary for V(D)J recombination in developing B and T lymphocytes. During NHEJ, Ku70 and Ku80 form a heterodimer that recognizes DSBs and promotes recruitment and function of downstream factors PAXX, MRI, DNA-PKcs, Artemis, ... -
Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population
Gago-Fuentes, Raquel; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-28)Non-homologous end-joining (NHEJ) is a major DNA repair pathway in mammalian cells that recognizes, processes and fixes DNA damage throughout the cell cycle and is specifically important for homeostasis of post-mitotic neurons and developing lymphocytes. Neuronal apoptosis increases in the mice lacking NHEJ factors Ku70 and Ku80. Inactivation of other NHEJ genes, either <i>Xrcc4</i> or <i>Lig4</i>, ...